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Title:

Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain.

Document type:
Journal Article; Article
Author(s):
Schneider, M; Ackermann, K; Stuart, M; Wex, C; Protzer, U; Schätzl, HM; Gilch, S
Abstract:
The ubiquitin-proteasome system (UPS) is involved in the replication of a broad range of viruses. Since replication of the murine hepatitis virus (MHV) is impaired upon proteasomal inhibition, the relevance of the UPS for the replication of the severe acute respiratory syndrome coronavirus (SARS-CoV) was investigated in this study. We demonstrate that the proteasomal inhibitor MG132 strongly inhibits SARS-CoV replication by interfering with early steps of the viral life cycle. Surprisingly, othe...     »
Journal title abbreviation:
J Virol
Year:
2012
Journal volume:
86
Journal issue:
18
Pages contribution:
10112-22
Language:
eng
Fulltext / DOI:
doi:10.1128/JVI.01001-12
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22787216
Print-ISSN:
0022-538X
TUM Institution:
Institut für Virologie
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