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Title:

Immune tolerance against HBV can be overcome in HBV transgenic mice by immunization with dendritic cells pulsed by HBVsvp.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Farag, MM; Tedjokusumo, R; Flechtenmacher, C; Asen, T; Stremmel, W; Muller, M; Protzer, U; Weigand, K
Abstract:
In chronic Hepatitis B Virus (HBV) infection the function of dendritic cells (DC), T- and B-cells is impaired. DC vaccination is an option to overcome this. DC pulsed in vitro with HBV sub viral particles (HBVsvp) and used to immunize mice can activate HBV directed humoral and cellular immune responses. In the present study we vaccinated HBV transgenic mice as a model for chronic HBV infection and observed humoral and cellular immune responses. In these mice, the lacking immune response against...     »
Journal title abbreviation:
Vaccine
Year:
2012
Journal volume:
30
Journal issue:
42
Pages contribution:
6034-9
Language:
eng
Fulltext / DOI:
doi:10.1016/j.vaccine.2012.07.057
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22867720
Print-ISSN:
0264-410X
TUM Institution:
Institut für Virologie
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