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Titel:

Follicular dendritic cells emerge from ubiquitous perivascular precursors.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Krautler, NJ; Kana, V; Kranich, J; Tian, Y; Perera, D; Lemm, D; Schwarz, P; Armulik, A; Browning, JL; Tallquist, M; Buch, T; Oliveira-Martins, JB; Zhu, C; Hermann, M; Wagner, U; Brink, R; Heikenwalder, M; Aguzzi, A
Abstract:
The differentiation of follicular dendritic cells (FDC) is essential to the remarkable microanatomic plasticity of lymphoid follicles. Here we show that FDC arise from ubiquitous perivascular precursors (preFDC) expressing platelet-derived growth factor receptor ? (PDGFR?). PDGFR?-Cre-driven reporter gene recombination resulted in FDC labeling, whereas conditional ablation of PDGFR?(+)-derived cells abolished FDC, indicating that FDC originate from PDGFR?(+) cells. Lymphotoxin-?-overexpressing p...     »
Zeitschriftentitel:
Cell
Jahr:
2012
Band / Volume:
150
Heft / Issue:
1
Seitenangaben Beitrag:
194-206
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.cell.2012.05.032
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22770220
Print-ISSN:
0092-8674
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Virologie
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