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Title:

The NF-?B signaling protein Bcl10 regulates actin dynamics by controlling AP1 and OCRL-bearing vesicles.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Marion, S; Mazzolini, J; Herit, F; Bourdoncle, P; Kambou-Pene, N; Hailfinger, S; Sachse, M; Ruland, J; Benmerah, A; Echard, A; Thome, M; Niedergang, F
Abstract:
The protein Bcl10 contributes to adaptive and innate immunity through the assembly of a signaling complex that plays a key role in antigen receptor and FcR-induced NF-?B activation. Here we demonstrate that Bcl10 has an NF-?B-independent role in actin and membrane remodeling downstream of FcR in human macrophages. Depletion of Bcl10 impaired Rac1 and PI3K activation and led to an abortive phagocytic cup rich in PI(4,5)P(2), Cdc42, and F-actin, which could be rescued with low doses of F-actin dep...     »
Journal title abbreviation:
Dev Cell
Year:
2012
Journal volume:
23
Journal issue:
5
Pages contribution:
954-67
Language:
eng
Fulltext / DOI:
doi:10.1016/j.devcel.2012.09.021
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23153494
Print-ISSN:
1534-5807
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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