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Titel:

The NF-?B signaling protein Bcl10 regulates actin dynamics by controlling AP1 and OCRL-bearing vesicles.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Marion, S; Mazzolini, J; Herit, F; Bourdoncle, P; Kambou-Pene, N; Hailfinger, S; Sachse, M; Ruland, J; Benmerah, A; Echard, A; Thome, M; Niedergang, F
Abstract:
The protein Bcl10 contributes to adaptive and innate immunity through the assembly of a signaling complex that plays a key role in antigen receptor and FcR-induced NF-?B activation. Here we demonstrate that Bcl10 has an NF-?B-independent role in actin and membrane remodeling downstream of FcR in human macrophages. Depletion of Bcl10 impaired Rac1 and PI3K activation and led to an abortive phagocytic cup rich in PI(4,5)P(2), Cdc42, and F-actin, which could be rescued with low doses of F-actin dep...     »
Zeitschriftentitel:
Dev Cell
Jahr:
2012
Band / Volume:
23
Heft / Issue:
5
Seitenangaben Beitrag:
954-67
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.devcel.2012.09.021
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23153494
Print-ISSN:
1534-5807
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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