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Document type:
Journal Article 
Author(s):
Luraghi, P; Schelter, F; Kruger, A; Boccaccio, C 
Title:
The MET Oncogene as a Therapeutical Target in Cancer Invasive Growth. 
Abstract:
The MET proto-oncogene, encoding the tyrosine kinase receptor for Hepatocyte Growth Factor (HGF) regulates invasive growth, a genetic program that associates control of cell proliferation with invasion of the extracellular matrix and protection from apoptosis. Physiologically, invasive growth takes place during embryonic development, and, in post-natal life, in wound healing and regeneration of several tissues. The MET oncogene is overexpressed and/or genetically mutated in many tumors, thereby...    »
 
Journal title abbreviation:
Front Pharmacol 
Year:
2012 
Journal volume:
Pages contribution:
164 
Language:
eng 
Fulltext / DOI:
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung