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Document type:
Journal Article
Author(s):
Anton, M; Wolf, A; Mykhaylyk, O; Koch, C; Gansbacher, B; Plank, C
Title:
Optimizing Adenoviral Transduction of Endothelial Cells under Flow Conditions.
Abstract:
To target adenoviral vectors to cells of the vasculature and shielding vectors from inactivation by the immune system.Complexes of reporter gene expressing adenoviral vectors with positively charged magnetic nanoparticles were formed by electrostatic interaction in presence or absence of additional negatively charged poly(ethylene glycol)-based polymer. Transduction of HUVEC was analyzed in vitro under flow. Protection from inactivation by the immune system was analyzed by pre-incubation of AdV...     »
Journal title abbreviation:
Pharm Res
Year:
2012
Journal volume:
29
Journal issue:
5
Pages contribution:
1219-31
Language:
eng
Fulltext / DOI:
doi:10.1007/s11095-011-0631-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22207207
Print-ISSN:
0724-8741
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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