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Title:

The use of non-viral gene vectors for bioactive poly-(D,L-lactide) implant surfaces in bone tissue engineering.

Document type:
In Vitro; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Reckhenrich, AK; Koch, C; Egana, JT; Plank, C
Abstract:
The application of scaffolds in bone tissue engineering often comes along with side effects such as poor integrity, low regeneration rates of bone tissue with inadequate functionality, and, in case of non-degradable implants, the necessity of a second removal surgery after therapy. In this study, we coated a bioresorbable FDA-approved poly-(?-caprolactone)-scaffold for bone regeneration with a poly-(D,L-lactide) layer containing copolymer-protected gene vectors to locally provide bone morphogene...     »
Journal title abbreviation:
Eur Cell Mater
Year:
2012
Journal volume:
23
Pages contribution:
441-8
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22736203
Print-ISSN:
1473-2262
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung; Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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