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Title:

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Goldmann, T; Wieghofer, P; Müller, PF; Wolf, Y; Varol, D; Yona, S; Brendecke, SM; Kierdorf, K; Staszewski, O; Datta, M; Luedde, T; Heikenwalder, M; Jung, S; Prinz, M
Abstract:
Microglia are brain macrophages and, as such, key immune-competent cells that can respond to environmental changes. Understanding the mechanisms of microglia-specific responses during pathologies is hence vital for reducing disease burden. The definition of microglial functions has so far been hampered by the lack of genetic in vivo approaches that allow discrimination of microglia from closely related peripheral macrophage populations in the body. Here we introduce a mouse experimental system t...     »
Journal title abbreviation:
Nat Neurosci
Year:
2013
Journal volume:
16
Journal issue:
11
Pages contribution:
1618-26
Language:
eng
Fulltext / DOI:
doi:10.1038/nn.3531
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24077561
Print-ISSN:
1097-6256
TUM Institution:
Institut für Virologie
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