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Title:

T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Krebs, K; Böttinger, N; Huang, LR; Chmielewski, M; Arzberger, S; Gasteiger, G; Jäger, C; Schmitt, E; Bohne, F; Aichler, M; Uckert, W; Abken, H; Heikenwalder, M; Knolle, P; Protzer, U
Abstract:
Antiviral agents suppress hepatitis B virus (HBV) replication but do not clear the infection. A strong effector T-cell response is required to eradicate HBV, but this does not occur in patients with chronic infection. T cells might be directed toward virus-infected cells by expressing HBV-specific receptors and thereby clear HBV and help to prevent development of liver cancer. In mice, we studied whether redirected T cells can engraft after adoptive transfer, without prior T-cell depletion, and...     »
Journal title abbreviation:
Gastroenterology
Year:
2013
Journal volume:
145
Journal issue:
2
Pages contribution:
456-65
Language:
eng
Fulltext / DOI:
doi:10.1053/j.gastro.2013.04.047
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23639914
Print-ISSN:
0016-5085
TUM Institution:
Institut für Virologie ; Roman Herzog Comprehensive Cancer Center
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