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Titel:

NADPH Oxidase Deficient Mice Develop Colitis and Bacteremia upon Infection with Normally Avirulent, TTSS-1- and TTSS-2-Deficient Salmonella Typhimurium.

Dokumenttyp:
Journal Article; Article
Autor(en):
Felmy, B; Songhet, P; Slack, EM; Müller, AJ; Kremer, M; Van Maele, L; Cayet, D; Heikenwalder, M; Sirard, JC; Hardt, WD
Abstract:
Infections, microbe sampling and occasional leakage of commensal microbiota and their products across the intestinal epithelial cell layer represent a permanent challenge to the intestinal immune system. The production of reactive oxygen species by NADPH oxidase is thought to be a key element of defense. Patients suffering from chronic granulomatous disease are deficient in one of the subunits of NADPH oxidase. They display a high incidence of Crohn's disease-like intestinal inflammation and are...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2013
Band / Volume:
8
Heft / Issue:
10
Seitenangaben Beitrag:
e77204
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0077204
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24143212
Print-ISSN:
1932-6203
TUM Einrichtung:
Institut für Virologie
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