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Title:

Rotational magnetic pulses enhance the magnetofection efficiency in vitro in adherent and suspension cells

Document type:
Journal Article
Author(s):
Dahmani, Ch; Mykhaylyk, O; Helling, Fl; Goetz, St; Weyh, Th; Herzog, H-G; Plank, Ch
Abstract:
The association of magnetic nanoparticles with gene delivery vectors in combination with the use of gradient magnetic fields (magnetofection) enables improved and synchronised gene delivery to cells. In this paper, we report a system comprising rotating permanent magnets to generate defined magnetic field pulses with frequencies from 2.66 to 133 Hz and a field amplitude of 190 or 310 mT at the location of the cells. Low-frequency pulses of 2.66-10 Hz with a magnetic flux density of 190 mT were a...     »
Journal title abbreviation:
J MAGN MAGN MATER
Year:
2013
Journal volume:
332
Pages contribution:
163-171
Language:
eng
Print-ISSN:
0304-8853
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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