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Title:

?4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Rothhammer, Veit; Muschaweckh, Andreas; Gasteiger, Georg; Petermann, Franziska; Heink, Sylvia; Busch, Dirk H; Heikenwälder, Mathias; Hemmer, Bernhard; Drexler, Ingo; Korn, Thomas
Abstract:
Natalizumab blocks ?4-integrins and is a prototypic agent for a series of anti-inflammatory drugs that impair trafficking of immune cells into the CNS. However, modulation of the access of immune cells to the CNS is associated with impaired immune surveillance and detrimental viral infections of the CNS. Here, we explored the potency of cellular immune responses within the CNS to protect against viral encephalitis in mice with T cell conditional disruption of VLA-4 integrin (?4?1) expression.Whi...     »
Journal title abbreviation:
Acta Neuropathol Commun
Year:
2014
Journal volume:
2
Pages contribution:
27
Language:
eng
Fulltext / DOI:
doi:10.1186/2051-5960-2-27
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24606807
Print-ISSN:
2051-5960
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Virologie ; Neurologische Klinik und Poliklinik
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