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Title:

Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion.

Document type:
journal article
Author(s):
Sprinzl, Martin Franz, MF; Puschnik, Andreas, A; Schlitter, Anna Melissa, AM; Schad, Arno, A; Ackermann, Kerstin, K; Esposito, Irene, I; Lang, Hauke, H; Galle, Peter Robert, PR; Weinmann, Arndt, A; Heikenwälder, Mathias, M; Protzer, Ulrike, U
Abstract:
Hepatocellular carcinoma (HCC) associated macrophages accelerate tumor progression by growth factor release. Therefore, tumor-associated macrophages (TAM) and their initiated signaling cascades are potential therapeutic targets. Aiming at understanding anticancer effects of systemic HCC therapy we investigated the impact of sorafenib on macrophage function, focusing on macrophage-related growth factor secretion.Macrophage markers, cytokine and growth factor release were investigated in CSF-1 (M1...     »
Journal title abbreviation:
J Hepatol
Year:
2014
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25463538
Print-ISSN:
0168-8278
TUM Institution:
Institut für Virologie
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