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Title:

Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.

Document type:
journal article
Author(s):
Lucifora, Julie, J; Xia, Yuchen, Y; Reisinger, Florian, F; Zhang, Ke, K; Stadler, Daniela, D; Cheng, Xiaoming, X; Sprinzl, Martin F, MF; Koppensteiner, Herwig, H; Makowska, Zuzanna, Z; Volz, Tassilo, T; Remouchamps, Caroline, C; Chou, Wen-Min, WM; Thasler, Wolfgang E, WE; Hüser, Norbert, N; Durantel, David, D; Liang, T Jake, TJ; Münk, Carsten, C; Heim, Markus H, MH; Browning, Jeffrey L, JL; Dejardin, Emmanuel, E; Dandri, Maura, M; Schindler, Michael, M; Heikenwalder, Mathias, M; Protzer, Ulrike,...     »
Abstract:
Current antiviral agents can control but not eliminate hepatitis B virus (HBV), because HBV establishes a stable nuclear covalently closed circular DNA (cccDNA). Interferon-? treatment can clear HBV but is limited by systemic side effects. We describe how interferon-? can induce specific degradation of the nuclear viral DNA without hepatotoxicity and propose lymphotoxin-? receptor activation as a therapeutic alternative. Interferon-? and lymphotoxin-? receptor activation up-regulated APOBEC3A an...     »
Journal title abbreviation:
Science
Year:
2014
Journal volume:
343
Journal issue:
6176
Pages contribution:
1221-8
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24557838
Print-ISSN:
0036-8075
TUM Institution:
Institut für Virologie
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