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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Koppensteiner, Herwig; Höhne, Kristin; Gondim, Marcos Vinicius; Gobert, Francois-Xavier; Widder, Miriam; Gundlach, Swantje; Heigele, Anke; Kirchhoff, Frank; Winkler, Michael; Benaroch, Philippe; Schindler, Michael
Titel:
Lentiviral Nef suppresses iron uptake in a strain specific manner through inhibition of Transferrin endocytosis.
Abstract:
Increased cellular iron levels are associated with high mortality in HIV-1 infection. Moreover iron is an important cofactor for viral replication, raising the question whether highly divergent lentiviruses actively modulate iron homeostasis. Here, we evaluated the effect on cellular iron uptake upon expression of the accessory protein Nef from different lentiviral strains.Surface Transferrin receptor (TfR) levels are unaffected by Nef proteins of HIV-1 and its simian precursors but elevated in...     »
Zeitschriftentitel:
Retrovirology
Jahr:
2014
Band / Volume:
11
Seitenangaben Beitrag:
1
Sprache:
eng
Volltext / DOI:
doi:10.1186/1742-4690-11-1
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24383984
TUM Einrichtung:
Institut für Virologie
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