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Title:

Microfibrillar-associated protein 4 modulates airway smooth muscle cell phenotype in experimental asthma.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Pilecki, Bartosz; Schlosser, Anders; Wulf-Johansson, Helle; Trian, Thomas; Moeller, Jesper B; Marcussen, Niels; Aguilar-Pimentel, Juan A; de Angelis, Martin Hrabe; Vestbo, Jorgen; Berger, Patrick; Holmskov, Uffe; Sorensen, Grith L
Abstract:
Recently, several proteins of the extracellular matrix have been characterised as active contributors to allergic airway disease. Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix protein abundant in the lung, whose biological functions remain poorly understood. In the current study we investigated the role of MFAP4 in experimental allergic asthma.MFAP4-deficient mice were subjected to alum/ovalbumin and house dust mite induced models of allergic airway disease. In addition,...     »
Journal title abbreviation:
Thorax
Year:
2015
Journal volume:
70
Journal issue:
9
Pages contribution:
862-72
Language:
eng
Fulltext / DOI:
doi:10.1136/thoraxjnl-2014-206609
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26038533
Print-ISSN:
0040-6376
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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