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Title:

Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kircher, Philipp; Hermanns, Constanze; Nossek, Maximilian; Drexler, Maria Katharina; Grosse, Robert; Fischer, Maximilian; Sarikas, Antonio; Penkava, Josef; Lewis, Thera; Prywes, Ron; Gudermann, Thomas; Muehlich, Susanne
Abstract:
Megakaryoblastic leukemia 1 (MKL1) is a coactivator of serum response factor (SRF) that promotes the expression of genes associated with cell proliferation, motility, adhesion, and differentiation-processes that also involve dynamic cytoskeletal changes in the cell. MKL1 is inactive when bound to monomeric globular actin (G-actin), but signals that activate the small guanosine triphosphatase RhoA cause actin polymerization and MKL1 dissociation from G-actin. We found a new mechanism of MKL1 acti...     »
Journal title abbreviation:
Sci Signal
Year:
2015
Journal volume:
8
Journal issue:
402
Pages contribution:
ra112
Language:
eng
Fulltext / DOI:
doi:10.1126/scisignal.aad2959
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26554816
Print-ISSN:
1945-0877
TUM Institution:
Institut für Pharmakologie und Toxikologie
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