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Titel:

Extracellular acidosis impairs P2Y receptor-mediated Ca(2+) signalling and migration of microglia.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Langfelder, Antonia; Okonji, Emeka; Deca, Diana; Wei, Wei-Chun; Glitsch, Maike D
Abstract:
Microglia are the resident macrophage and immune cell of the brain and are critically involved in combating disease and assaults on the brain. Virtually all brain pathologies are accompanied by acidosis of the interstitial fluid, meaning that microglia are exposed to an acidic environment. However, little is known about how extracellular acidosis impacts on microglial function. The activity of microglia is tightly controlled by 'on' and 'off' signals, the presence or absence of which results in...     »
Zeitschriftentitel:
Cell Calcium
Jahr:
2015
Band / Volume:
57
Heft / Issue:
4
Seitenangaben Beitrag:
247-56
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.ceca.2015.01.004
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25623949
Print-ISSN:
0143-4160
TUM Einrichtung:
Institut für Neurowissenschaften
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