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Title:

?-Secretase processing of APP inhibits neuronal activity in the hippocampus.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Willem, Michael; Tahirovic, Sabina; Busche, Marc Aurel; Ovsepian, Saak V; Chafai, Magda; Kootar, Scherazad; Hornburg, Daniel; Evans, Lewis D B; Moore, Steven; Daria, Anna; Hampel, Heike; Müller, Veronika; Giudici, Camilla; Nuscher, Brigitte; Wenninger-Weinzierl, Andrea; Kremmer, Elisabeth; Heneka, Michael T; Thal, Dietmar R; Giedraitis, Vilmantas; Lannfelt, Lars; Müller, Ulrike; Livesey, Frederick J; Meissner, Felix; Herms, Jochen; Konnerth, Arthur; Marie, Hélène; Haass, Christian
Abstract:
Alzheimer disease (AD) is characterized by the accumulation of amyloid plaques, which are predominantly composed of amyloid-? peptide. Two principal physiological pathways either prevent or promote amyloid-? generation from its precursor, ?-amyloid precursor protein (APP), in a competitive manner. Although APP processing has been studied in great detail, unknown proteolytic events seem to hinder stoichiometric analyses of APP metabolism in vivo. Here we describe a new physiological APP processin...     »
Journal title abbreviation:
Nature
Year:
2015
Journal volume:
526
Journal issue:
7573
Pages contribution:
443-7
Language:
eng
Fulltext / DOI:
doi:10.1038/nature14864
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26322584
Print-ISSN:
0028-0836
TUM Institution:
Institut für Neurowissenschaften; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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