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Titel:

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Carambia, Antonella; Freund, Barbara; Schwinge, Dorothee; Bruns, Oliver T; Salmen, Sunhild C; Ittrich, Harald; Reimer, Rudolph; Heine, Markus; Huber, Samuel; Waurisch, Christian; Eychmüller, Alexander; Wraith, David C; Korn, Thomas; Nielsen, Peter; Weller, Horst; Schramm, Christoph; Lüth, Stefan; Lohse, Ansgar W; Heeren, Joerg; Herkel, Johannes
Abstract:
It is well-known that the liver can induce immune tolerance, yet this knowledge could, thus far, not be translated into effective treatments for autoimmune diseases. We have previously shown that liver sinusoidal endothelial cells (LSECs) could substantially contribute to hepatic tolerance through their ability to induce CD4+ Foxp3+ regulatory T cells (Tregs). Here, we explored whether the Treg-inducing potential of LSECs could be harnessed for the treatment of autoimmune disease.We engineered a...     »
Zeitschriftentitel:
J Hepatol
Jahr:
2015
Band / Volume:
62
Heft / Issue:
6
Seitenangaben Beitrag:
1349-56
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jhep.2015.01.006
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25617499
Print-ISSN:
0168-8278
TUM Einrichtung:
Molekulare Immunologie (Prof. Knolle)
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