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Titel:

Clinical Significance of NOTCH1 and NOTCH2 Expression in Gastric Carcinomas: An Immunohistochemical Study.

Dokumenttyp:
Journal Article
Autor(en):
Bauer, Lukas; Takacs, Agnes; Slotta-Huspenina, Julia; Langer, Rupert; Becker, Karen; Novotny, Alexander; Ott, Katja; Walch, Axel; Hapfelmeier, Alexander; Keller, Gisela
Abstract:
NOTCH signaling can exert oncogenic or tumor suppressive functions and can contribute to chemotherapy resistance in cancer. In this study, we aimed to clarify the clinicopathological significance and the prognostic and predictive value of NOTCH1 and NOTCH2 expression in gastric cancer (GC).NOTCH1 and NOTCH2 expression was determined immunohistochemically in 142 primarily resected GCs using tissue microarrays and in 84 pretherapeutic biopsies from patients treated by neoadjuvant chemotherapy. The...     »
Zeitschriftentitel:
Front Oncol
Jahr:
2015
Band / Volume:
5
Seitenangaben Beitrag:
94
Sprache:
eng
Volltext / DOI:
doi:10.3389/fonc.2015.00094
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25954607
Print-ISSN:
2234-943X
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Statistik und Epidemiologie
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