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Title:

Identification of a Novel Immunodominant HLA-B*07: 02-restricted Adenoviral Peptide Epitope and Its Potential in Adoptive Transfer Immunotherapy.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Günther, Patrick S; Peper, Janet K; Faist, Benjamin; Kayser, Simone; Hartl, Lena; Feuchtinger, Tobias; Jahn, Gerhard; Neuenhahn, Michael; Busch, Dirk H; Stevanovi?, Stefan; Dennehy, Kevin M
Abstract:
Adenovirus infections of immunocompromised patients, particularly following allogeneic hematopoietic stem cell transplantation, are associated with morbidity and mortality. Immunotherapy by adoptive transfer of hexon-specific and penton-specific T cells has been successfully applied, but many approaches are impeded by the low number of HLA class I-restricted adenoviral peptide epitopes described to date. We use a novel method to identify naturally presented adenoviral peptide epitopes from infec...     »
Journal title abbreviation:
J Immunother
Year:
2015
Journal volume:
38
Journal issue:
7
Pages contribution:
267-75
Language:
eng
Fulltext / DOI:
doi:10.1097/CJI.0000000000000087
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26261890
Print-ISSN:
1524-9557
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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