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Dokumenttyp:
journal article 
Autor(en):
Liu, Jimmy Z; van Sommeren, Suzanne; Huang, Hailiang; Ng, Siew C; Alberts, Rudi; Takahashi, Atsushi; Ripke, Stephan; Lee, James C; Jostins, Luke; Shah, Tejas; Abedian, Shifteh; Cheon, Jae Hee; Cho, Judy; Daryani, Naser E; Franke, Lude; Fuyuno, Yuta; Hart, Ailsa; Juyal, Ramesh C; Juyal, Garima; Kim, Won Ho; Morris, Andrew P; Poustchi, Hossein; Newman, William G; Midha, Vandana; Orchard, Timothy R; Vahedi, Homayon; Sood, Ajit; Sung, Joseph J Y; Malekzadeh, Reza; Westra, Harm-Jan; Yamazaki, Keiko;...    »
 
Titel:
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. 
Abstract:
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease (IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or Immunochip genotype data from an extended cohort of 86,640 European individuals and Immunochip data from 9,846 individuals of East Asian, Indian or Iranian descent. We implicate 38 loci in IBD risk for the first time. For the majority of the IBD risk loci, the direction and magnitude of effect are consistent in Eu...    »
 
Zeitschriftentitel:
Nat Genet 
Jahr:
2015 
Band / Volume:
47 
Heft / Issue:
Seitenangaben Beitrag:
979-86 
Sprache:
eng 
Volltext / DOI:
Print-ISSN:
1061-4036 
TUM Einrichtung:
Institut für Humangenetik