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Titel:

Early recognition of lung cancer by integrin targeted imaging in K-ras mouse model.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Ermolayev, Vladimir; Mohajerani, Pouyan; Ale, Angelique; Sarantopoulos, Athanasios; Aichler, Michaela; Kayser, Gian; Walch, Axel; Ntziachristos, Vasilis
Abstract:
Non-small cell lung cancer is characterized by slow progression and high heterogeneity of tumors. Integrins play an important role in lung cancer development and metastasis and were suggested as a tumor marker; however their role in anticancer therapy remains controversial. In this work, we demonstrate the potential of integrin-targeted imaging to recognize early lesions in transgenic mouse model of lung cancer based on spontaneous introduction of mutated human gene bearing K-ras mutation. We c...     »
Zeitschriftentitel:
Int J Cancer
Jahr:
2015
Band / Volume:
137
Heft / Issue:
5
Seitenangaben Beitrag:
1107-18
Sprache:
eng
Volltext / DOI:
doi:10.1002/ijc.29372
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25450481
Print-ISSN:
0020-7136
TUM Einrichtung:
Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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