Influence of Different Neoadjuvant Chemotherapy Regimens on Response, Prognosis, and Complication Rate in Patients with Esophagogastric Adenocarcinoma.

Springfeld, Christoph; Wiecha, Christiane; Kunzmann, Romy; Heger, Ulrike; Weichert, Wilko; Langer, Rupert; Stange, Annika; Blank, Susanne; Sisic, Leila; Schmidt, Thomas; Lordick, Florian; Jäger, Dirk; Grenacher, Lars; Bruckner, Tom; Büchler, Markus W; Ott, Katja

doi:10.1245/s10434-015-4617-x

Benutzer: Gast

Institut für Allgemeine Pathologie und Pathologische Anatomie

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Titel:: Influence of Different Neoadjuvant Chemotherapy Regimens on Response, Prognosis, and Complication Rate in Patients with Esophagogastric Adenocarcinoma.
Dokumenttyp:: Journal Article
Autor(en):: Springfeld, Christoph; Wiecha, Christiane; Kunzmann, Romy; Heger, Ulrike; Weichert, Wilko; Langer, Rupert; Stange, Annika; Blank, Susanne; Sisic, Leila; Schmidt, Thomas; Lordick, Florian; Jäger, Dirk; Grenacher, Lars; Bruckner, Tom; Büchler, Markus W; Ott, Katja
Abstract:: Perioperative chemotherapy improves survival in patients with advanced esophagogastric cancer, but the optimal treatment regimen remains unclear. More intensive chemotherapy may improve outcome, but also increase toxicity and complications.A total of 843 patients were included in this retrospective study and stratified in 4 groups: doublet therapy with cisplatin or oxaliplatin and 5-fluorouracil (groups A/B) or triplet therapy with additional epirubicin or taxane (groups C/D). The influence of the different neoadjuvant chemotherapy regimens on response, prognosis, and complications was assessed.Clinical and pathological response were associated with longer overall survival (OS; p < 0.001). No significant differences regarding response or OS were found, but there was a trend toward better outcome in group D (taxane-containing triplet). In the subgroup of 669 patients with adenocarcinomas of the esophagogastric junction (AEG), patients who had received taxane-containing regimens had a significantly longer OS (p = 0.037), but taxane use was not an independent factor in multivariate analysis. Triple therapy with taxanes did not result in a higher complication rate or postoperative mortality.Although no superior neoadjuvant chemotherapy regimen was identified for patients with esophagogastric adenocarcinoma, taxane-containing regimens should be further investigated in randomized trials, especially in patients with AEG tumors.
Zeitschriftentitel:: Ann Surg Oncol
Jahr:: 2015
Band / Volume:: 22 Suppl 3
Seitenangaben Beitrag:: S905-14
Sprache:: eng
Volltext / DOI:: doi:10.1245/s10434-015-4617-x
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/26001861
Print-ISSN:: 1068-9265
TUM Einrichtung:: Institut für Allgemeine Pathologie und Pathologische Anatomie
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