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Title:

Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes.

Document type:
Journal Article; Journal Article
Author(s):
Diakopoulos, Kalliope N; Lesina, Marina; Wörmann, Sonja; Song, Liang; Aichler, Michaela; Schild, Lorenz; Artati, Anna; Römisch-Margl, Werner; Wartmann, Thomas; Fischer, Robert; Kabiri, Yashar; Zischka, Hans; Halangk, Walter; Demir, Ihsan Ekin; Pilsak, Claudia; Walch, Axel; Mantzoros, Christos S; Steiner, Jörg M; Erkan, Mert; Schmid, Roland M; Witt, Heiko; Adamski, Jerzy; Algül, Hana
Abstract:
Little is known about the mechanisms of the progressive tissue destruction, inflammation, and fibrosis that occur during development of chronic pancreatitis. Autophagy is involved in multiple degenerative and inflammatory diseases, including pancreatitis, and requires the protein autophagy related 5 (ATG5). We created mice with defects in autophagy to determine its role in pancreatitis.We created mice with pancreas-specific disruption of Atg5 (Ptf1aCreex1; Atg5F/F mice) and compared them to cont...     »
Journal title abbreviation:
Gastroenterology
Year:
2015
Journal volume:
148
Journal issue:
3
Pages contribution:
626-638.e17
Language:
eng
Fulltext / DOI:
doi:10.1053/j.gastro.2014.12.003
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25497209
Print-ISSN:
0016-5085
TUM Institution:
Chirurgische Klinik und Poliklinik; Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin; II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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