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Titel:

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Journal Article
Autor(en):
Claussnitzer, Melina; Dankel, Simon N; Kim, Kyoung-Han; Quon, Gerald; Meuleman, Wouter; Haugen, Christine; Glunk, Viktoria; Sousa, Isabel S; Beaudry, Jacqueline L; Puviindran, Vijitha; Abdennur, Nezar A; Liu, Jannel; Svensson, Per-Arne; Hsu, Yi-Hsiang; Drucker, Daniel J; Mellgren, Gunnar; Hui, Chi-Chung; Hauner, Hans; Kellis, Manolis
Abstract:
Genomewide association studies can be used to identify disease-relevant genomic regions, but interpretation of the data is challenging. The FTO region harbors the strongest genetic association with obesity, yet the mechanistic basis of this association remains elusive.We examined epigenomic data, allelic activity, motif conservation, regulator expression, and gene coexpression patterns, with the aim of dissecting the regulatory circuitry and mechanistic basis of the association between the FTO r...     »
Zeitschriftentitel:
N Engl J Med
Jahr:
2015
Band / Volume:
373
Heft / Issue:
10
Seitenangaben Beitrag:
895-907
Sprache:
eng
Volltext / DOI:
doi:10.1056/NEJMoa1502214
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26287746
Print-ISSN:
0028-4793
TUM Einrichtung:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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