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Title:

L-type Calcium Channel Cav1.2 Is Required for Maintenance of Auditory Brainstem Nuclei.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Ebbers, Lena; Satheesh, Somisetty V; Janz, Katrin; Rüttiger, Lukas; Blosa, Maren; Hofmann, Franz; Morawski, Markus; Griesemer, Désirée; Knipper, Marlies; Friauf, Eckhard; Nothwang, Hans Gerd
Abstract:
Cav1.2 and Cav1.3 are the major L-type voltage-gated Ca(2+) channels in the CNS. Yet, their individual in vivo functions are largely unknown. Both channel subunits are expressed in the auditory brainstem, where Cav1.3 is essential for proper maturation. Here, we investigated the role of Cav1.2 by targeted deletion in the mouse embryonic auditory brainstem. Similar to Cav1.3, loss of Cav1.2 resulted in a significant decrease in the volume and cell number of auditory nuclei. Contrary to the deleti...     »
Journal title abbreviation:
J Biol Chem
Year:
2015
Journal volume:
290
Journal issue:
39
Pages contribution:
23692-710
Language:
eng
Fulltext / DOI:
doi:10.1074/jbc.M115.672675
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26242732
Print-ISSN:
0021-9258
TUM Institution:
Institut für Pharmakologie und Toxikologie
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