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Titel:

A microfluidics approach to study the accumulation of molecules at basal lamina interfaces

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Arends, Fabienna; Sellner, Sabine; Seifert, Philipp; Gerland, Ulrich; Rehberg, Markus; Lieleg, Oliver
Abstract:
For an efficient distribution of drugs and drug carriers through biological barriers such as the vascular system, the size and surface properties of nanoparticles and molecules play a key role. To screen for important parameters which determine the ability of drugs or drug carriers to translocate through complex biological barriers, an in vitro assay which correctly predicts the behavior of those objects in vivo would be highly desirable. Here, we present a microfluidic setup to probe the diffus...     »
Stichworte:
drug carrier, basal lamina, vascular system, biological barrier
Dewey Dezimalklassifikation:
500 Naturwissenschaften
Zeitschriftentitel:
Lab Chip
Jahr:
2015
Band / Volume:
15
Heft / Issue:
16
Seitenangaben Beitrag:
3326-3334
Nachgewiesen in:
Web of Science
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1039/c5lc00561b
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26152353
WWW:
http://pubs.rsc.org/en/Content/ArticleLanding/2015/LC/C5LC00561B#!divAbstract
Verlag / Institution:
Royal Society of Chemistry (RSC)
Verlagsort:
England
Print-ISSN:
1473-0189
Publikationsdatum:
01.01.2015
TUM Einrichtung:
Fachgebiet für Biomechanik
Eingabe:
12.08.2015
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