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- Titel:
Two decades of hepatitis B vaccination in mentally retarded patients: effectiveness, antibody persistence and duration of immune memory.
- Dokumenttyp:
- Journal Article; Research Support, Non-U.S. Gov't; Article
- Autor(en):
- Braeckman, T; Van Herck, K; Jilg, W; Bauer, T; Van Damme, P
- Abstract:
- Institutionalized mentally retarded subjects are well-known to be at-risk for HBV infection. We studied the persistence of vaccine-induced anti-HBs antibodies and the robustness of the HBsAg-specific immune memory in this population, 18-20 years after the first vaccine dose.Non-immune residents of 4 institutions were immunized in 1984-1986. In 2004, 207 subjects were bled to determine humoral and cellular immune memory. Immune response to a booster dose was evaluated in subjects with anti-HBs level <100 IU/L.Four subjects showed anti-HBc seroconversion, without clinical implications. Pre-booster anti-HBs levels <100 IU/L were found in 45 subjects (22%); 34/39 (87%) responded with a rapid and high anti-HBs titer to the booster dose. Robust T and B cell memory was present pre- and post-booster.Overall results confirm that hepatitis B vaccines are highly effective and immunogenic, and confer long-term persistence of antibodies and immune memory in an at-risk population.
- Zeitschriftentitel:
- Vaccine
- Jahr:
- 2012
- Band / Volume:
- 30
- Heft / Issue:
- 32
- Seitenangaben Beitrag:
- 4757-61
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1016/j.vaccine.2012.05.044
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/22652400
- Print-ISSN:
- 0264-410X
- TUM Einrichtung:
- Institut für Virologie
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