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Title:

Silica-iron oxide magnetic nanoparticles modified for gene delivery: a search for optimum and quantitative criteria.

Document type:
Journal Article
Author(s):
Mykhaylyk, O; Sobisch, T; Almstätter, I; Sánchez-Antequera, Y; Brandt, S; Anton, M; Doblinger, M; Eberbeck, D; Settles, M; Braren, R; Lerche, D; Plank, C
Abstract:
To optimize silica-iron oxide magnetic nanoparticles with surface phosphonate groups decorated with 25-kD branched polyethylenimine (PEI) for gene delivery.Surface composition, charge, colloidal stabilities, associations with adenovirus, magneto-tranduction efficiencies, cell internalizations, in vitro toxicities and MRI relaxivities were tested for the particles decorated with varying amounts of PEI.Moderate PEI-decoration of MNPs results in charge reversal and destabilization. Analysis of spac...     »
Journal title abbreviation:
Pharm Res
Year:
2012
Journal volume:
29
Journal issue:
5
Pages contribution:
1344-65
Language:
eng
Fulltext / DOI:
doi:10.1007/s11095-011-0661-9
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22222384
Print-ISSN:
0724-8741
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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