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Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Beyerle, A; Braun, A; Banerjee, A; Ercal, N; Eickelberg, O; Kissel, TH; Stoeger, T
Title:
Inflammatory responses to pulmonary application of PEI-based siRNA nanocarriers in mice.
Abstract:
Polymeric non-viral vector systems for pulmonary application of siRNA are promising carriers, but have failed to enter clinical trials because of safety and efficiency problems. Therefore, improving their transfection efficiency, as well as their toxicological profile, is the subject of intensive research efforts. Six different poly(ethylene imine) (PEI)-based nanocarriers, with hydrophilic and hydrophobic PEG modifications, were toxicologically evaluated for pulmonary application in mice. Nanoc...    »
Journal title abbreviation:
Biomaterials
Year:
2011
Journal volume:
32
Journal issue:
33
Pages contribution:
8694-701
Language:
eng
Print-ISSN:
0142-9612
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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