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Title:

FoxP3, GATA-3 and T-bet expression in elderly asthma.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Vale-Pereira, S; Todo-Bom, A; Geraldes, L; Schmidt-Weber, C; Akdis, CA; Mota-Pinto, A
Abstract:
Asthma is a chronic inflammatory disorder in which Th2, Th1 and suppressive T cells (Tregs) play a role. The transcription factor FoxP3 plays a role in Treg differentiation while T-bet is important for Th1 and GATA-3 for Th2 differentiation from naïve T cells. Recent data show that age-related deregulation of Treg cells is a mechanism of senescence affecting several chronic diseases. It is crucial to understand the behaviour of these cell populations in asthma for elderly patients.To evaluate Fo...     »
Journal title abbreviation:
Clin Exp Allergy
Year:
2011
Journal volume:
41
Journal issue:
4
Pages contribution:
490-6
Language:
eng
Fulltext / DOI:
doi:10.1111/j.1365-2222.2010.03640.x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21114556
Print-ISSN:
0954-7894
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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