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Title:

Loss of endogenous RNF43 function enhances proliferation and tumour growth of intestinal and gastric cells.

Document type:
Journal Article
Author(s):
Neumeyer, Victoria; Grandl, Martina; Dietl, Alisa; Brutau-Abia, Anna; Allgäuer, Michael; Kalali, Behnam; Zhang, Yang; Pan, Kai-Feng; Steiger, Katja; Vieth, Michael; Anton, Martina; Mejías-Luque, Raquel; Gerhard, Markus
Abstract:
Ring finger protein 43 (RNF43) is an E3 ubiquitin ligase that has been described to be frequently mutated in gastrointestinal cancers. RNF43 downregulation was associated with distant metastasis, TNM stage and poorer survival in patients with gastric and colorectal cancers. Functional analysis has shown that overexpressed RNF43 negatively regulates Wnt signalling by ubiquitinating Frizzled receptors and targeting them for degradation and by sequestering T-cell factor 4 (TCF4) to the nuclear memb...     »
Journal title abbreviation:
Carcinogenesis
Year:
2019
Journal volume:
40
Journal issue:
4
Pages contribution:
551-559
Language:
eng
Fulltext / DOI:
doi:10.1093/carcin/bgy152
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30380024
Print-ISSN:
0143-3334
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Experimentelle Onkologie und Therapieforschung; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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