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Titel:

A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Płaszczyca, Anna; Scaturro, Pietro; Neufeldt, Christopher John; Cortese, Mirko; Cerikan, Berati; Ferla, Salvatore; Brancale, Andrea; Pichlmair, Andreas; Bartenschlager, Ralf
Abstract:
Dengue virus (DENV) has emerged as major human pathogen. Despite the serious socio-economic impact of DENV-associated diseases, antiviral therapy is missing. DENV replicates in the cytoplasm of infected cells and induces a membranous replication organelle, formed by invaginations of the endoplasmic reticulum membrane and designated vesicle packets (VPs). Nonstructural protein 1 (NS1) of DENV is a multifunctional protein. It is secreted from cells to counteract antiviral immune responses, but als...     »
Zeitschriftentitel:
PLoS Pathog
Jahr:
2019
Band / Volume:
15
Heft / Issue:
5
Volltext / DOI:
doi:10.1371/journal.ppat.1007736
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31071189
Print-ISSN:
1553-7366
TUM Einrichtung:
Institut für Virologie
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