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Title:

Connecting lysosomes and mitochondria - a novel role for lipid metabolism in cancer cell death.

Document type:
Journal Article
Author(s):
Bartel, Karin; Pein, Helmut; Popper, Bastian; Schmitt, Sabine; Janaki-Raman, Sudha; Schulze, Almut; Lengauer, Florian; Koeberle, Andreas; Werz, Oliver; Zischka, Hans; Müller, Rolf; Vollmar, Angelika M; von Schwarzenberg, Karin
Abstract:
BACKGROUND: The understanding of lysosomes has been expanded in recent research way beyond their view as cellular trash can. Lysosomes are pivotal in regulating metabolism, endocytosis and autophagy and are implicated in cancer. Recently it was discovered that the lysosomal V-ATPase, which is known to induce apoptosis, interferes with lipid metabolism in cancer, yet the interplay between these organelles is poorly understood. METHODS: LC-MS/MS analysis was performed to investigate lipid distribu...     »
Journal title abbreviation:
Cell Commun Signal
Year:
2019
Journal volume:
17
Journal issue:
1
Fulltext / DOI:
doi:10.1186/s12964-019-0399-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31358011
Print-ISSN:
1478-811X
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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