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Title:

Prognostic implication of molecular subtypes and response to neoadjuvant chemotherapy in 760 gastric carcinomas: role of Epstein-Barr virus infection and high- and low-microsatellite instability.

Document type:
Journal Article
Author(s):
Kohlruss, Meike; Grosser, Bianca; Krenauer, Marie; Slotta-Huspenina, Julia; Jesinghaus, Moritz; Blank, Susanne; Novotny, Alexander; Reiche, Magdalena; Schmidt, Thomas; Ismani, Liridona; Hapfelmeier, Alexander; Mathias, Daniel; Meyer, Petra; Gaida, Matthias M; Bauer, Lukas; Ott, Katja; Weichert, Wilko; Keller, Gisela
Abstract:
Epstein-Barr virus positivity (EBV(+)) and high-microsatellite instability (MSI-H) have been identified as molecular subgroups in gastric carcinoma. The aim of our study was to determine the prognostic and predictive relevance of these subgroups in the context of platinum/5-fluorouracil (5-FU) based preoperative chemotherapy (CTx). Additionally, we investigated the clinical relevance of the low-MSI (MSI-L) phenotype. We analysed 760 adenocarcinomas of the stomach or the gastro-oesophageal juncti...     »
Journal title abbreviation:
J Pathol Clin Res
Year:
2019
Journal volume:
5
Journal issue:
4
Pages contribution:
227-239
Fulltext / DOI:
doi:10.1002/cjp2.137
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31206244
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Statistik und Epidemiologie; Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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