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Title:

Maximizing the Translational Yield of mRNA Therapeutics by Minimizing 5'-UTRs.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Trepotec, Zeljka; Aneja, Manish K; Geiger, Johannes; Hasenpusch, Guenther; Plank, Christian; Rudolph, Carsten
Abstract:
The 5'-untranslated region (5'-UTR) of mRNA contains structural elements, which are recognized by cell-specific RNA-binding proteins, thereby affecting the translation of the molecule. The activation of an innate immune response upon transfection of mRNA into cells is reduced when the mRNA comprises chemically modified nucleotides, putatively by altering the secondary structure of the molecule. Such alteration in the 5'-UTR in turn may affect the functionality of mRNA. In this study, we report o...     »
Journal title abbreviation:
Tissue Eng Part A
Year:
2019
Journal volume:
25
Journal issue:
1-2
Pages contribution:
69-79
Fulltext / DOI:
doi:10.1089/ten.tea.2017.0485
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29638193
Print-ISSN:
1937-3341
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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