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Titel:

Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Melnik, Svitlana; Werth, Nadine; Boeuf, Stephane; Hahn, Eva-Maria; Gotterbarm, Tobias; Anton, Martina; Richter, Wiltrud
Abstract:
BACKGROUND: Mesenchymal stromal cells isolated from bone marrow (MSC) represent an attractive source of adult stem cells for regenerative medicine. However, thorough research is required into their clinical application safety issues concerning a risk of potential neoplastic degeneration in a process of MSC propagation in cell culture for therapeutic applications. Expansion protocols could preselect MSC with elevated levels of growth-promoting transcription factors with oncogenic potential, such...     »
Zeitschriftentitel:
Stem Cell Res Ther
Jahr:
2019
Band / Volume:
10
Heft / Issue:
1
Volltext / DOI:
doi:10.1186/s13287-019-1187-z
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30836996
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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