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Title:

The uric acid crystal receptor Clec12A potentiates type I interferon responses.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Li, Kai; Neumann, Konstantin; Duhan, Vikas; Namineni, Sukumar; Hansen, Anne Louise; Wartewig, Tim; Kurgyis, Zsuzsanna; Holm, Christian K; Heikenwalder, Mathias; Lang, Karl S; Ruland, Jürgen
Abstract:
The detection of microbes and damaged host cells by the innate immune system is essential for host defense against infection and tissue homeostasis. However, how distinct positive and negative regulatory signals from immune receptors are integrated to tailor specific responses in complex scenarios remains largely undefined. Clec12A is a myeloid cell-expressed inhibitory C-type lectin receptor that can sense cell death under sterile conditions. Clec12A detects uric acid crystals and limits proinf...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2019
Journal volume:
116
Journal issue:
37
Pages contribution:
18544-18549
Fulltext / DOI:
doi:10.1073/pnas.1821351116
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31451663
Print-ISSN:
0027-8424
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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