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Titel:

Comprehensive Detection of Isopeptides between Human Tissue Transglutaminase and Gluten Peptides

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Lexhaller; Ludwig; Scherf
Abstract:
Celiac disease (CD) is a chronic inflammation of the small intestine triggered by the ingestion of gluten in genetically predisposed individuals. Tissue transglutaminase (TG2) is a key factor in CD pathogenesis, because it catalyzes both the deamidation of specific glutamine residues and the formation of covalent Nε-(γ-glutamyl)-lysine isopeptide crosslinks resulting in TG2-gluten peptide complexes. These complexes are thought to activate B cells causing the secretion of anti-TG2 autoantibodies...     »
Stichworte:
BayBioMS; LC-MS/MS; celiac disease; crosslink; deamidation; gliadin; gluten; isopeptides; tissue transglutaminase; transamidation
Zeitschriftentitel:
Nutrients
Jahr:
2019
Band / Volume:
11
Heft / Issue:
10
Seitenangaben Beitrag:
2263
Volltext / DOI:
doi:10.3390/nu11102263
Verlag / Institution:
MDPI AG
E-ISSN:
2072-6643
Publikationsdatum:
20.09.2019
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