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Title:

The muscle size-regulating enzyme PKM2 limits myofiber growth in vitro and increases in response to resistance exercise in human skeletal muscle

Document type:
Zeitschriftenaufsatz
Author(s):
Verbrugge S, Gehlert S, Stadhouders L, Jacko D, Aussieker T, de Wit G, Offringa C, Schönfelder M, Jaspers R, Wackerhage H
Abstract:
Nearly 100 years ago, Otto Warburg investigated the metabolism of growing tissues and discovered that tumors reprogram their metabolism. It is poorly understood whether and how hypertrophying muscle, another growing tissue, reprograms its metabolism too. Here, we studied pyruvate kinase muscle (PKM), which can be spliced into two isoforms (PKM1, PKM2). This is of interest, because PKM2 redirects glycolytic flux towards biosynthetic pathways, which might contribute to muscle hypertrophy too. We f...     »
Keywords:
Warburg effect; pyruvate kinase; insulin-like growth factor 1; glycolysis; skeletal muscle; hypertrophy; resistance exercise; metabolic reprogramming; cancer
Dewey Decimal Classification:
570 Biowissenschaften, Biologie; 610 Medizin und Gesundheit
Journal title:
International Journal of Molecular Sciences -Biochemistry
Year:
2020
Year / month:
2020-09
Quarter:
3. Quartal
Month:
Sep
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.3390/ijms21197062
WWW:
https://www.mdpi.com/journal/ijms/sections/biochemistry
Print-ISSN:
1422-0067
Impact Factor:
4,556
Scimago Quartil:
Q1
Notes:
SCImago Journal &  Country Rank
Accepted:
23.09.2020
Semester:
SS 20
TUM Institution:
Sportbiologie
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