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Titel:

Aldehyde dehydrogenase 1A3 (ALDH1A3) is regulated by autophagy in human glioblastoma cells.

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Wu W, Schecker J, Wuerstle S, Schneider F, Schoenfelder M, Schlegel J
Abstract:
Aldehyde dehydrogenase is a polymorphic enzyme, which responsible for the oxidation of aldehydes. It has been shown that ALDH1A3 is expressed in human glioblastomas and that its expression correlates with a worse prognosis. In our present study ALDH1A3 expression was associated with resistance against Temozolomide (TMZ) treatment and sensitivity could be re-established in ALDH1A3 knockout cells. TMZ treatment at high concentrations diminished ALDH1A3 protein and this downregulation made the tum...     »
Stichworte:
ALDH; Aldehyde dehydrogenase; Autophagy; Chemoresistance; Glioblastoma
Dewey Dezimalklassifikation:
610 Medizin und Gesundheit
Zeitschriftentitel:
Cancer Letters
Jahr:
2018
Jahr / Monat:
2018-01
Monat:
Jan
Heft / Issue:
417
Seitenangaben Beitrag:
112-123
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1016/j.canlet.2017.12.036
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29306018
Verlag / Institution:
Elsevier
Print-ISSN:
0304-3835
E-ISSN:
1872-7980
Impact Factor:
5.851
Semester:
WS 17-18
TUM Einrichtung:
Sportbiologie
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