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Title:

Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Haas, Darya A; Meiler, Arno; Geiger, Katharina; Vogt, Carola; Preuss, Ellen; Kochs, Georg; Pichlmair, Andreas
Abstract:
Viruses have evolved a plethora of mechanisms to target host antiviral responses. Here, we propose a yet uncharacterized mechanism of immune regulation by the orthomyxovirus Thogoto virus (THOV) ML protein through engaging general transcription factor TFIIB. ML generates a TFIIB depleted nuclear environment by re-localizing it into the cytoplasm. Although a broad effect on gene expression would be anticipated, ML expression, delivery of an ML-derived functional domain or experimental depletion o...     »
Journal title abbreviation:
PLoS Pathog
Year:
2018
Journal volume:
14
Journal issue:
4
Fulltext / DOI:
doi:10.1371/journal.ppat.1006980
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29709033
Print-ISSN:
1553-7366
TUM Institution:
Institut für Virologie
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