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Titel:

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Holze, Cathleen; Michaudel, Chloé; Mackowiak, Claire; Haas, Darya A; Benda, Christian; Hubel, Philipp; Pennemann, Friederike L; Schnepf, Daniel; Wettmarshausen, Jennifer; Braun, Marianne; Leung, Daisy W; Amarasinghe, Gaya K; Perocchi, Fabiana; Staeheli, Peter; Ryffel, Bernhard; Pichlmair, Andreas
Abstract:
Reactive oxygen species (ROS) are generated by virus-infected cells; however, the physiological importance of ROS generated under these conditions is unclear. Here we found that the inflammation and cell death induced by exposure of mice or cells to sources of ROS were not altered in the absence of canonical ROS-sensing pathways or known cell-death pathways. ROS-induced cell-death signaling involved interactions among the cellular ROS sensor and antioxidant factor KEAP1, the phosphatase PGAM5 a...     »
Zeitschriftentitel:
Nat Immunol
Jahr:
2018
Band / Volume:
19
Heft / Issue:
2
Seitenangaben Beitrag:
130-140
Volltext / DOI:
doi:10.1038/s41590-017-0013-y
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29255269
Print-ISSN:
1529-2908
TUM Einrichtung:
Institut für Virologie
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