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Titel:

Chromatin-Remodeling Factor SPOC1 Acts as a Cellular Restriction Factor against Human Cytomegalovirus by Repressing the Major Immediate Early Promoter.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Reichel, Anna; Stilp, Anne-Charlotte; Scherer, Myriam; Reuter, Nina; Lukassen, Sören; Kasmapour, Bahram; Schreiner, Sabrina; Cicin-Sain, Luka; Winterpacht, Andreas; Stamminger, Thomas
Abstract:
The cellular protein SPOC1 (survival time-associated PHD [plant homeodomain] finger protein in ovarian cancer 1) acts as a regulator of chromatin structure and the DNA damage response. It binds H3K4me2/3-containing chromatin and promotes DNA condensation by recruiting corepressors such as KAP-1 and H3K9 methyltransferases. Previous studies identified SPOC1 as a restriction factor against human adenovirus (HAdV) infection that is antagonized by E1B-55K/E4-orf6-dependent proteasomal degradation. H...     »
Zeitschriftentitel:
J Virol
Jahr:
2018
Band / Volume:
92
Heft / Issue:
14
Volltext / DOI:
doi:10.1128/JVI.00342-18
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29743358
Print-ISSN:
0022-538X
TUM Einrichtung:
Institut für Virologie
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