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Titel:

ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis.

Dokumenttyp:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Das, Koushik K; Heeg, Steffen; Pitarresi, Jason R; Reichert, Maximilian; Bakir, Basil; Takano, Shigetsugu; Kopp, Janel L; Wahl-Feuerstein, Anja; Hicks, Philip; Sander, Maike; Rustgi, Anil K
Abstract:
BACKGROUND: The plasticity of pancreatic acinar cells to undergo acinar to ductal metaplasia (ADM) has been demonstrated to contribute to the regeneration of the pancreas in response to injury. Sox9 is critical for ductal cell fate and important in the formation of ADM, most likely in concert with a complex hierarchy of, as yet, not fully elucidated transcription factors. RESULTS: By using a mouse model of acute pancreatitis and three dimensional organoid culture of primary pancreatic ductal cel...     »
Zeitschriftentitel:
Dev Dyn
Jahr:
2018
Band / Volume:
247
Heft / Issue:
6
Seitenangaben Beitrag:
854-866
Volltext / DOI:
doi:10.1002/dvdy.24626
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29532564
Print-ISSN:
1058-8388
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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