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Title:

Mining the Human Tissue Proteome for Protein Citrullination

Document type:
Zeitschriftenaufsatz
Author(s):
Lee, Chien-Yun; Wang, Dongxue; Wilhelm, Mathias; Zolg, Daniel P.; Schmidt, Tobias; Schnatbaum, Karsten; Reimer, Ulf; Pontén, Fredrik; Uhlén, Mathias; Hahne, Hannes; Kuster, Bernhard
Abstract:
Citrullination is a posttranslational modification of arginine catalyzed by five peptidylarginine deiminases (PADs) in humans. The loss of a positive charge may cause structural or functional alterations, and while the modification has been linked to several diseases, including rheumatoid arthritis (RA) and cancer, its physiological or pathophysiological roles remain largely unclear. In part, this is owing to limitations in available methodology to robustly enrich, detect, and localize the modif...     »
Keywords:
Data evaluation; Omics; Post-translational modifications*; Tandem Mass Spectrometry; Tissues*; citrullination; human proteome; peptidylarginine deiminase; synthetic peptides
Journal title:
Molecular & Cellular Proteomics
Year:
2018
Journal volume:
17
Journal issue:
7
Pages contribution:
1378-1391
Fulltext / DOI:
doi:10.1074/mcp.ra118.000696
Publisher:
American Society for Biochemistry & Molecular Biology (ASBMB)
E-ISSN:
1535-94761535-9484
Date of publication:
02.04.2018
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