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Titel:

Mining the Human Tissue Proteome for Protein Citrullination

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Lee, Chien-Yun; Wang, Dongxue; Wilhelm, Mathias; Zolg, Daniel P.; Schmidt, Tobias; Schnatbaum, Karsten; Reimer, Ulf; Pontén, Fredrik; Uhlén, Mathias; Hahne, Hannes; Kuster, Bernhard
Abstract:
Citrullination is a posttranslational modification of arginine catalyzed by five peptidylarginine deiminases (PADs) in humans. The loss of a positive charge may cause structural or functional alterations, and while the modification has been linked to several diseases, including rheumatoid arthritis (RA) and cancer, its physiological or pathophysiological roles remain largely unclear. In part, this is owing to limitations in available methodology to robustly enrich, detect, and localize the modif...     »
Stichworte:
Data evaluation; Omics; Post-translational modifications*; Tandem Mass Spectrometry; Tissues*; citrullination; human proteome; peptidylarginine deiminase; synthetic peptides
Zeitschriftentitel:
Molecular & Cellular Proteomics
Jahr:
2018
Band / Volume:
17
Heft / Issue:
7
Seitenangaben Beitrag:
1378-1391
Volltext / DOI:
doi:10.1074/mcp.ra118.000696
Verlag / Institution:
American Society for Biochemistry & Molecular Biology (ASBMB)
E-ISSN:
1535-94761535-9484
Publikationsdatum:
02.04.2018
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